PREX-1979: Modeling the first ever prototype of a new generation of microbicides for preventing HIV infection among high risk women
نویسنده
چکیده
Impregnating a proteolytic substrate of specifity to viral envelope with a restriction enzyme cleaving the HIV genome could generate a novel line of microbicide. Web Cutter version 2.0 aimed at identifying which enzyme can cleave HIV-1 and 2 genomes in 10 or > cuts was employed. Computational analysis indicate that of 291, 17 (5.8%) enzymes had 10 or more cuts in the HIV1/SIVcpz genome as compared to 25 (8.9%) for HIV-2/SIVsmm with 6 enzymes (Eco-130I, EcoT141, ApoI, AcsI, BssTII, and StyI) having a mutual ability to cleave HIV-1 and 2 in 10 and more cuts. Although not a proteolytic enzyme, the surfactant Savvy/C31G (Cellegy) was identified as a safe and close candidate for our proteolytic substrate. With biochemical compound modeling, it is possible to stably impregnate the center of surfactant/detergent molecule with a natural product. The PREX Model may be explored to develop novel lines of microbicides aimed at preventing HIV and other viral STI transmission in humans
منابع مشابه
Predictors of Safer Conception Practices Among HIV-Infected Women in Northern Nigeria
Background Persons living with HIV often face discrimination in safe sex and reproductive choices, especially in lowresource settings. This study assessed fertility desires and intentions, risk perception and correlates of ever use of at least one safer conception method among HIV-infected women attending a tertiary health facility ...
متن کاملMucocutaneous manifestations as the first presentations of HIV infection
Background: Mucocutaneous manifestations may occur inevery stage of human immunodeficiency virus (HIV) infection.Some of them may be the first presentations. In this study, weevaluated the prevalence of dermatologic manifestations as thefirst presentations of HIV/AIDS in 25 Iranian patients.Method: In a cross sectional study, we evaluated 25 new casesof HIV infection whose HIV infections were d...
متن کاملPrevalence of sexually transmitted infections based on syndromic approach and associated factors among Iranian women
Background and purpose: Reproductive and sexual health related problems constitute one third of health problems among women aged 15 to 44 years. Sexually transmitted infections are a significant challenge for human development. We aimed to assess the prevalence of STIs and identify factors associated with among Iranian women. Materials and Methods: Through a cross-sectional study, 399 women ...
متن کاملCost-effectiveness of Methadone Maintenance Treatment Centers in Prevention of Human Immunodeficiency Virus Infection
Background: Acquired immune deficiency syndrome (AIDS) is one of the greatest social health problems in many communities in the twenty-first century. Methadone maintenance treatment (MMT) could decrease HIV infection among injection drug users (IDU). The main aim of this paper was to determine the cost-effectiveness of the governmental MMT program to prevent human immunodeficiency virus (HIV) i...
متن کاملرفتارهای پرخطر افراد مبتلا به عفونت HIV در مراجعان به مراکز مشاوره بیماریهای رفتاری دانشگاههای علوم پزشکی شهرتهران
Introduction: Development of effective antiretroviral therapies (ART) has reduced mortality and increased life expectancy among individuals with HIV infection. Antiretroviral therapy regiments have improved symptoms and quality of life among these patients, whose sexual and reproductive needs, have, therefore, increased as well. In 2010, 20.8% of HIV-infected Iranians acquired the disease throu...
متن کامل